How to use the native driver that comes build into the linux kernel. Here are the steps to recompile the kernel in FC6: In Linux source directory, e.g., /usr/src/linux-2.6.18 * make menuconfig In Device Drivers->Character Devices->Serial Drivers->, configure "Maximum number of 8250/16550 serial ports" "Number of 8250/16550 serial ports to register at Runtime" to the required number of COM ports and ISI ports * make modules * make modules_install * make install